Cee-Lo took over regional attention as a member of the hip hop group Goodie Mob. Between 1995 and 1999 they published three commercially  unsuccessful albums. After he launched a solo career,  he came out in 2002 with his self-produced debut album, "Cee-Lo Green and His Perfect Imperfections".

In 2004 his second album, "Cee-Lo Green ... Is the Soul Machine" was published. With the help of hit producers such as Timbaland, Jazze Pha and The Neptunes and guest contributions from Pharrell, TI Ludacris  it reached number 13 on the Billboard charts.

Cee-Lo is also a member of "the Dungeon Family", a hip-hop group that was founded in the early 1990s. In 2001 their only album "Even in Darkness" came out. Cee-Lo sings in almost half of the songs.

Cee-Lo Green is also a very successful songwriter for other artists. He wrote and produced for Amerie, Kelis, Brandy, Jennifer Hudson and Solange Knowles. In 2005, in collaboration with the Pussycat Dolls and Busta Rhymes, Cee-Lo had the Number One hit "Don't Cha", in which he sang the background vocals. He also did on another number-one song "Waterfalls" by "TLC".

He has been involved as a guest singer with P. Diddy, Common, Nas, Kelis, Twista, Usher Roth, Everlast, The Black Eyed Peas, Carlos Santana and German dancehall band Seeed ("Get Up!") Heard.

In February 2011  Cee-Lo Green won the Brit Award for best international artist.